|Project Title||Wearable High-Throughput Photoacoustic Screening and Photothermal Killing of Circulating Melanoma Cells|
As the most fatal type of skin cancers, melanoma is a major public health problem in U.S. A considerable patient population with advanced metastatic melanoma does not respond to the FDA-approved drugs and thus still suffer high mortality. Because most deaths of melanoma are caused by bloodstream spread of circulating melanoma cells (CMCs) into distant organs and their subsequent growth into overt metastases, noninvasive detection and clearing of CMCs represents a highly promising diagnosis and treatment strategy
Combining high-sensitivity and high-throughput photoacoustic detection and high-efficiency photothermal elimination, this invention represents a novel wearable technology, which is capable of simultaneous fast screening and killing of CMCs in vivo, approaching the treatment of melanoma metastasis entirely from a physical perspective. The photoacoustic detection can screen CMCs in the entire human blood volume within a few hours. This high-throughput screening is enabled by a fast MEMS (microelectromechanical systems) scanning on deeper blood vessels with higher blood flows. By using short laser pulses of suitable wavelength to heat melanosomes inside CMCs to evaporation temperature, CMCs can be mechanically ruptured without damaging surround cells or tissues, thereby causing no side effects of the treatment.
Stage of Development
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Nature methods, 2015.
Wang, L., et al.
“Photoacoustic imaging of single circulating melanoma cells in vivo.”
International Society for Optics and Photonics, 2015.
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|Tags||photothermal, screening, ablation, circulating melanoma cells, photoacoustic|
|Posted Date||Apr 18, 2017 4:18 PM|
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